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1 Understanding Orforglipron Orforglipron is a nonpeptide GLP-1 receptor agonist that functions by stimulating insulin release from the pancreas and slowing gastric emptying, which can promote satiety, reduce food intake, and lead to weight loss
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Zepbound (Tirzepatide): As one of the most effective options available, Zepbound acts on both GLP-1 and GIP receptors, maximizing weight loss potential to around 20.9% body weight reduction in clinical trials
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